Assay Detail
Functional
CHEMBL781258
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity against synaptic membrane from rat brain using [3H](S)-Glu as the radioligand
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Excitatory amino acid agonists. Enzymic resolution, X-ray structure, and enantioselective activities of (R)- and (S)-bromohomoibotenic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.45 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL73069 | — | — | 1 | 6.82 |
| CHEMBL73698 | — | — | 1 | 6.70 |
| CHEMBL71073 | — | — | 1 | 6.66 |
| CHEMBL76232 | D-GLUTAMATE | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL73069 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL73698 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL71073 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL76232 | D-GLUTAMATE | IC50 | = | 2500.0 | nM | 5.60 |