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Assay Detail

CHEMBL700005

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of calcium ionophore (A23187) stimulated LTB4 formation in human neutrophils
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 6 — Multiple protein complex / RNA
Curated By Expert

Target

5-lipoxygenase/FLAP (CHEMBL2111402)
Type PROTEIN COMPLEX
Organism Homo sapiens

Publication

O-alkylcarboxylate oxime and N-hydroxyurea analogs of substituted indole leukotriene biosynthesis inhibitors
Woods KW, Brooks CD, Maki RG, Rodriques KE, Bouska JB, Young P, Bell RL, Carter GW
Bioorg Med Chem Lett (1996) 6 : 1547 -1552
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 5.71 7.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL29097 1 7.52
CHEMBL3349448 1 7.00
CHEMBL290170 1 6.82
CHEMBL39189 1 6.77
CHEMBL434401 1 6.75
CHEMBL3349449 1 6.57
CHEMBL3349447 1 6.47
CHEMBL289751 1 5.40
CHEMBL289586 1 5.16
CHEMBL16596 QUIFLAPON 2.0 1 5.10
CHEMBL38545 1 5.00
CHEMBL38949 1 5.00
CHEMBL36331 1 4.96
CHEMBL38884 1 4.92
CHEMBL444304 1 4.92
CHEMBL38513 1 4.89
CHEMBL39617 1 4.77
CHEMBL40073 1 4.77

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL29097 IC50 = 30.0 nM 7.52
CHEMBL3349448 IC50 = 100.0 nM 7.00
CHEMBL290170 IC50 = 150.0 nM 6.82
CHEMBL39189 IC50 = 170.0 nM 6.77
CHEMBL434401 IC50 = 180.0 nM 6.75
CHEMBL3349449 IC50 = 270.0 nM 6.57
CHEMBL3349447 IC50 = 340.0 nM 6.47
CHEMBL289751 IC50 = 4000.0 nM 5.40
CHEMBL289586 IC50 = 7000.0 nM 5.16
CHEMBL16596 QUIFLAPON IC50 = 8000.0 nM 5.10
CHEMBL38545 IC50 = 10000.0 nM 5.00
CHEMBL38949 IC50 = 10000.0 nM 5.00
CHEMBL36331 IC50 = 11000.0 nM 4.96
CHEMBL38884 IC50 = 12000.0 nM 4.92
CHEMBL444304 IC50 = 12000.0 nM 4.92
CHEMBL38513 IC50 = 13000.0 nM 4.89
CHEMBL39617 IC50 = 17000.0 nM 4.77
CHEMBL40073 IC50 = 17000.0 nM 4.77