Assay Detail
Binding
CHEMBL700080
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]-isradipine binding to L-type [Ca2+] channel of rat brain membranes
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Voltage-gated L-type calcium channel (CHEMBL2095177) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Interaction of 1,4-dihydropyridine and pyridine derivatives with adenosine receptors: selectivity for A3 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.34 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2051956 | DEXNIGULDIPINE | 2.0 | 1 | 7.22 |
| CHEMBL2112411 | — | — | 1 | 6.16 |
| CHEMBL102138 | — | — | 1 | 6.04 |
| CHEMBL100646 | — | — | 1 | 5.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2051956 | DEXNIGULDIPINE | Ki | = | 59.7 | nM | 7.22 |
| CHEMBL2112411 | — | Ki | = | 694.0 | nM | 6.16 |
| CHEMBL102138 | — | Ki | = | 910.0 | nM | 6.04 |
| CHEMBL100646 | — | Ki | = | 1170.0 | nM | 5.93 |