Assay Detail
Functional
CHEMBL700227
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Compound was tested for cytotoxicity against K562 cell lines
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biologic activity of 2'-fluoro-2-halo derivatives of 9-beta-D-arabinofuranosyladenine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.29 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1750 | CLOFARABINE | 4.0 | 1 | 8.52 |
| CHEMBL3143080 | — | — | 1 | 7.30 |
| CHEMBL1568 | FLUDARABINE | 3.0 | 1 | 6.82 |
| CHEMBL2092969 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1750 | CLOFARABINE | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3143080 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1568 | FLUDARABINE | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL2092969 | — | IC50 | = | 300.0 | nM | 6.52 |