Assay Detail
Functional
CHEMBL700270
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Concentration to inhibit growth of normal rat K-ras-transformed cells (KNRK 5.2 cells) after 72 hr exposure
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antitumor activity of novel O-carbamoylmethyloxime derivatives of radicicol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.77 | 8.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL83070 | — | — | 1 | 8.19 |
| CHEMBL83069 | — | — | 1 | 7.85 |
| CHEMBL85011 | — | — | 1 | 7.41 |
| CHEMBL314705 | — | — | 1 | 7.41 |
| CHEMBL313587 | — | — | 1 | 7.35 |
| CHEMBL313882 | — | — | 1 | 7.14 |
| CHEMBL315521 | — | — | 1 | 7.09 |
| CHEMBL414883 | RADICICOL | — | 1 | 6.96 |
| CHEMBL83305 | — | — | 1 | 6.92 |
| CHEMBL85730 | — | — | 1 | 6.85 |
| CHEMBL85010 | — | — | 1 | 6.64 |
| CHEMBL85612 | — | — | 1 | 6.62 |
| CHEMBL311607 | — | — | 1 | 6.54 |
| CHEMBL82750 | — | — | 1 | 6.47 |
| CHEMBL84564 | — | — | 1 | 6.42 |
| CHEMBL419849 | — | — | 1 | 6.32 |
| CHEMBL84714 | — | — | 1 | 6.24 |
| CHEMBL315575 | — | — | 1 | 5.82 |
| CHEMBL82435 | — | — | 1 | 5.66 |
| CHEMBL84809 | — | — | 1 | 5.54 |
| CHEMBL85583 | — | — | 1 | - |
| CHEMBL312559 | — | — | 1 | - |
| CHEMBL85532 | — | — | 1 | - |
| CHEMBL84955 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL83070 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL83069 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL85011 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL314705 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL313587 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL313882 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL315521 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL414883 | RADICICOL | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL83305 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL85730 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL85010 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL85612 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL311607 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL82750 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL84564 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL419849 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL84714 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL315575 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL82435 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL84809 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL85583 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL312559 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL85532 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL84955 | — | IC50 | > | 3000.0 | nM | - |