Assay Detail
Functional
CHEMBL700276
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Growth inhibition against human KYSE-150 cell lines
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KYSE-150 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis, X-ray crystal structures, stabilities, and in vitro cytotoxic activities of new heteroarylacrylonitriles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.10 | 6.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL440896 | — | — | 1 | 6.48 |
| CHEMBL331583 | — | — | 1 | 6.28 |
| CHEMBL430890 | — | — | 1 | 6.25 |
| CHEMBL116696 | — | — | 1 | 6.21 |
| CHEMBL323906 | — | — | 1 | 6.20 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.16 |
| CHEMBL117966 | — | — | 1 | 6.12 |
| CHEMBL11359 | CISPLATIN | 4.0 | 1 | 6.06 |
| CHEMBL117076 | — | — | 1 | 6.05 |
| CHEMBL113815 | — | — | 1 | 5.87 |
| CHEMBL117195 | — | — | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL440896 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL331583 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL430890 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL116696 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL323906 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL117966 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL117076 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL113815 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL117195 | — | IC50 | = | 3360.0 | nM | 5.47 |