Assay Detail
Functional
CHEMBL700379
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of LFA-1 mediated JY-8 cell adhesion to ICAM-1, range(2-8)
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | JY-8 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Intercellular adhesion molecule (ICAM-1), Integrin alpha-L/beta-2 (CHEMBL2096661) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction. 4. Structure-activity relationship of substituents on the benzene ring of the cinnamide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 10.00 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL336789 | — | — | 1 | 10.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL336789 | — | IC50 | = | 0.1 | nM | 10.00 |