Assay Detail
Functional
CHEMBL700474
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Inhibition of aggregation of human gel-filtered platelets was measured by light transmittance method.
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Non-peptide glycoprotein IIb/IIIa inhibitors. 17. Design and synthesis of orally active, long-acting non-peptide fibrinogen receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.43 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL298655 | — | — | 1 | 8.10 |
| CHEMBL40502 | — | — | 1 | 8.05 |
| CHEMBL300525 | — | — | 1 | 8.00 |
| CHEMBL48371 | — | — | 1 | 7.50 |
| CHEMBL540024 | — | — | 1 | 6.60 |
| CHEMBL300097 | — | — | 1 | 6.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL298655 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL40502 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL300525 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL48371 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL540024 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL300097 | — | IC50 | = | 470.0 | nM | 6.33 |