Assay Detail
Functional
CHEMBL700477
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Inhibitory activity against ADP-induced platelet aggregation using human platelet rich plasma at a concentration of 4 uM by functional assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Molecular design of novel PGI2 agonists without PG skeleton. II
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.49 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL494 | ILOPROST | 4.0 | 1 | 8.85 |
| CHEMBL495 | ALPROSTADIL | 4.0 | 1 | 7.16 |
| CHEMBL416334 | — | — | 1 | 7.16 |
| CHEMBL274806 | — | — | 1 | 6.89 |
| CHEMBL268477 | AP-227 | — | 1 | 6.82 |
| CHEMBL11088 | — | — | 1 | 6.64 |
| CHEMBL10742 | — | — | 1 | 5.96 |
| CHEMBL418338 | — | — | 1 | 5.72 |
| CHEMBL10470 | — | — | 1 | 5.68 |
| CHEMBL10829 | — | — | 1 | 5.62 |
| CHEMBL10853 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL494 | ILOPROST | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL495 | ALPROSTADIL | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL416334 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL274806 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL268477 | AP-227 | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL11088 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL10742 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL418338 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL10470 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL10829 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL10853 | — | IC50 | = | 12000.0 | nM | 4.92 |