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Assay Detail

CHEMBL700494

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Binding
Inhibition against induced Nitric Oxide Synthase(iNOS)
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Nitric oxide synthase, inducible (CHEMBL3464)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

1H-pyrazole-1-carboxamidines: new inhibitors of nitric oxide synthase.
Lee Y, Martásek P, Roman LJ, Silverman RB.
Bioorg Med Chem Lett (2000) 10 : 2771 -2774
PubMed 11133088 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 15 5.24 6.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL262040 1 6.92
CHEMBL96680 1 6.80
CHEMBL542185 1 6.16
CHEMBL541572 1 5.52
CHEMBL554323 1 5.30
CHEMBL554676 1 5.05
CHEMBL94821 1 4.92
CHEMBL543616 1 4.85
CHEMBL542183 1 4.66
CHEMBL553998 1 4.30
CHEMBL545487 1 4.30
CHEMBL543853 1 4.10
CHEMBL553974 1 -
CHEMBL545486 1 -
CHEMBL544554 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL262040 Ki = 120.0 nM 6.92
CHEMBL96680 Ki = 160.0 nM 6.80
CHEMBL542185 Ki = 700.0 nM 6.16
CHEMBL541572 Ki = 3000.0 nM 5.52
CHEMBL554323 Ki = 5000.0 nM 5.30
CHEMBL554676 Ki = 9000.0 nM 5.05
CHEMBL94821 Ki = 12000.0 nM 4.92
CHEMBL543616 Ki = 14000.0 nM 4.85
CHEMBL542183 Ki = 22000.0 nM 4.66
CHEMBL553998 Ki = 50000.0 nM 4.30
CHEMBL545487 Ki = 50000.0 nM 4.30
CHEMBL543853 Ki = 80000.0 nM 4.10
CHEMBL553974 Ki = 750000.0 nM -
CHEMBL545486 Ki = 780000.0 nM -
CHEMBL544554 Ki = 150000.0 nM -