Assay Detail
Binding
CHEMBL700496
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against human inducible nitric oxide synthase (iNOS).
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Substituted N-phenylisothioureas: potent inhibitors of human nitric oxide synthase with neuronal isoform selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 5.01 | 6.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL545673 | — | — | 1 | 6.06 |
| CHEMBL543085 | — | — | 1 | 5.85 |
| CHEMBL543098 | — | — | 1 | 5.72 |
| CHEMBL552598 | — | — | 1 | 5.62 |
| CHEMBL543090 | — | — | 1 | 5.60 |
| CHEMBL541296 | — | — | 1 | 5.54 |
| CHEMBL540783 | — | — | 1 | 5.51 |
| CHEMBL544504 | — | — | 1 | 5.50 |
| CHEMBL553216 | — | — | 1 | 5.50 |
| CHEMBL543806 | — | — | 1 | 5.38 |
| CHEMBL552893 | — | — | 1 | 5.33 |
| CHEMBL545439 | — | — | 1 | 5.31 |
| CHEMBL540280 | — | — | 1 | 5.18 |
| CHEMBL543566 | — | — | 1 | 5.00 |
| CHEMBL542859 | — | — | 1 | 4.66 |
| CHEMBL542856 | — | — | 1 | 4.66 |
| CHEMBL542125 | — | — | 1 | 4.64 |
| CHEMBL542126 | — | — | 1 | 4.64 |
| CHEMBL553038 | — | — | 1 | 4.60 |
| CHEMBL539508 | — | — | 1 | 4.55 |
| CHEMBL555805 | — | — | 1 | 4.54 |
| CHEMBL542855 | — | — | 1 | 4.43 |
| CHEMBL538001 | — | — | 1 | 4.38 |
| CHEMBL552682 | — | — | 1 | 4.36 |
| CHEMBL543092 | — | — | 1 | 4.27 |
| CHEMBL554651 | — | — | 1 | 4.26 |
| CHEMBL545670 | — | — | 1 | 4.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL545673 | — | Ki | = | 870.0 | nM | 6.06 |
| CHEMBL543085 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL543098 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL552598 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL543090 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL541296 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL540783 | — | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL544504 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL553216 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL543806 | — | Ki | = | 4200.0 | nM | 5.38 |
| CHEMBL552893 | — | Ki | = | 4700.0 | nM | 5.33 |
| CHEMBL545439 | — | Ki | = | 4900.0 | nM | 5.31 |
| CHEMBL540280 | — | Ki | = | 6600.0 | nM | 5.18 |
| CHEMBL543566 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL542859 | — | Ki | = | 22000.0 | nM | 4.66 |
| CHEMBL542856 | — | Ki | = | 22000.0 | nM | 4.66 |
| CHEMBL542125 | — | Ki | = | 23000.0 | nM | 4.64 |
| CHEMBL542126 | — | Ki | = | 23000.0 | nM | 4.64 |
| CHEMBL553038 | — | Ki | = | 25000.0 | nM | 4.60 |
| CHEMBL539508 | — | Ki | = | 28000.0 | nM | 4.55 |
| CHEMBL555805 | — | Ki | = | 29000.0 | nM | 4.54 |
| CHEMBL542855 | — | Ki | = | 37000.0 | nM | 4.43 |
| CHEMBL538001 | — | Ki | = | 42000.0 | nM | 4.38 |
| CHEMBL552682 | — | Ki | = | 44000.0 | nM | 4.36 |
| CHEMBL543092 | — | Ki | = | 54000.0 | nM | 4.27 |
| CHEMBL554651 | — | Ki | = | 55000.0 | nM | 4.26 |
| CHEMBL545670 | — | Ki | = | 63000.0 | nM | 4.20 |