Assay Detail
Binding
CHEMBL700502
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In vitro inhibition of inducible nitric oxide synthase.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Dihydroquinolines as novel n-NOS inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.15 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL256147 | TILARGININE | 3.0 | 1 | 6.00 |
| CHEMBL315967 | — | — | 1 | 5.96 |
| CHEMBL315617 | — | — | 1 | 5.96 |
| CHEMBL85823 | — | — | 1 | 5.85 |
| CHEMBL86040 | — | — | 1 | 5.77 |
| CHEMBL314943 | — | — | 1 | 5.64 |
| CHEMBL83397 | — | — | 1 | 5.58 |
| CHEMBL315966 | — | — | 1 | 5.39 |
| CHEMBL86961 | — | — | 1 | 5.29 |
| CHEMBL227744 | NITROARGININE | 1.0 | 1 | 5.26 |
| CHEMBL292099 | — | — | 1 | 5.24 |
| CHEMBL7890 | L-NAME | 2.0 | 1 | 5.10 |
| CHEMBL83569 | — | — | 1 | 4.92 |
| CHEMBL85613 | — | — | 1 | 4.89 |
| CHEMBL85523 | — | — | 1 | 4.85 |
| CHEMBL87969 | — | — | 1 | 4.82 |
| CHEMBL87968 | — | — | 1 | 4.52 |
| CHEMBL83455 | — | — | 1 | 4.50 |
| CHEMBL314186 | — | — | 1 | 4.46 |
| CHEMBL87219 | — | — | 1 | 4.11 |
| CHEMBL313001 | — | — | 1 | 4.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL256147 | TILARGININE | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL315967 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL315617 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL85823 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL86040 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL314943 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL83397 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL315966 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL86961 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL227744 | NITROARGININE | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL292099 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL7890 | L-NAME | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL83569 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL85613 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL85523 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL87969 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL87968 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL83455 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL314186 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL87219 | — | IC50 | = | 78000.0 | nM | 4.11 |
| CHEMBL313001 | — | IC50 | = | 89000.0 | nM | 4.05 |