Assay Detail
Binding
CHEMBL700503
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Inhibition of human inducible nitric oxide synthase
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Inhibition of inducible nitric oxide synthase by acetamidine derivatives of hetero-substituted lysine and homolysine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.36 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL435854 | — | — | 1 | 6.16 |
| CHEMBL155129 | — | — | 1 | 5.92 |
| CHEMBL155413 | — | — | 1 | 5.85 |
| CHEMBL114551 | GW-274150 | 2.0 | 1 | 5.85 |
| CHEMBL340800 | — | — | 1 | 5.80 |
| CHEMBL351787 | — | — | 1 | 5.27 |
| CHEMBL155316 | — | — | 1 | 5.23 |
| CHEMBL256147 | TILARGININE | 3.0 | 1 | 5.18 |
| CHEMBL157958 | — | — | 1 | 5.10 |
| CHEMBL154895 | — | — | 1 | 5.10 |
| CHEMBL127739 | — | — | 1 | 4.70 |
| CHEMBL158297 | — | — | 1 | 4.21 |
| CHEMBL157074 | — | — | 1 | - |
| CHEMBL157190 | — | — | 1 | - |
| CHEMBL155318 | — | — | 1 | - |
| CHEMBL157846 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL435854 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL155129 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL155413 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL114551 | GW-274150 | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL340800 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL351787 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL155316 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL256147 | TILARGININE | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL157958 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL154895 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL127739 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL158297 | — | IC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL157074 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL157190 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL155318 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL157846 | — | IC50 | > | 100000.0 | nM | - |