Assay Detail
Binding
CHEMBL700505
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Concentration required to inhibit human Inducible nitric oxide synthase over expressed in A549 cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | A549 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of orally bioavailable inhibitors of inducible nitric oxide synthase. Part 1: synthesis and biological evaluation of dihydropyridin-2-imines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.44 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL72316 | — | — | 1 | 7.30 |
| CHEMBL75496 | — | — | 1 | 7.22 |
| CHEMBL75428 | — | — | 1 | 6.77 |
| CHEMBL75304 | — | — | 1 | 6.70 |
| CHEMBL75484 | — | — | 1 | 6.51 |
| CHEMBL308310 | — | — | 1 | 6.38 |
| CHEMBL76342 | — | — | 1 | 6.16 |
| CHEMBL260277 | — | — | 1 | 5.92 |
| CHEMBL74679 | — | — | 1 | 5.85 |
| CHEMBL75794 | — | — | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL72316 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL75496 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL75428 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL75304 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL75484 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL308310 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL76342 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL260277 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL74679 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL75794 | — | IC50 | = | 2800.0 | nM | 5.55 |