Assay Detail
Binding
CHEMBL700509
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Inhibitory activity against inducible nitric oxide synthase (iNOS)
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Substituted 2-aminopyridines as inhibitors of nitric oxide synthases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 6.05 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6808 | — | — | 1 | 7.80 |
| CHEMBL294609 | — | — | 1 | 7.55 |
| CHEMBL292507 | — | — | 1 | 7.34 |
| CHEMBL61427 | — | — | 1 | 7.23 |
| CHEMBL61939 | — | — | 1 | 7.12 |
| CHEMBL60372 | — | — | 1 | 7.12 |
| CHEMBL299677 | — | — | 1 | 6.96 |
| CHEMBL59925 | — | — | 1 | 6.96 |
| CHEMBL302657 | — | — | 1 | 6.96 |
| CHEMBL40833 | — | — | 1 | 6.77 |
| CHEMBL62077 | — | — | 1 | 6.64 |
| CHEMBL294084 | — | — | 1 | 6.48 |
| CHEMBL61990 | — | — | 1 | 6.22 |
| CHEMBL293022 | — | — | 1 | 6.09 |
| CHEMBL291544 | — | — | 1 | 6.03 |
| CHEMBL61599 | — | — | 1 | 5.89 |
| CHEMBL7889 | L-NIL | — | 1 | 5.85 |
| CHEMBL61236 | — | — | 1 | 5.77 |
| CHEMBL21619 | 2-AMINOPYRIDINE | — | 1 | 5.72 |
| CHEMBL61591 | — | — | 1 | 5.70 |
| CHEMBL292981 | — | — | 1 | 5.57 |
| CHEMBL58492 | — | — | 1 | 5.40 |
| CHEMBL60528 | — | — | 1 | 5.39 |
| CHEMBL62083 | — | — | 1 | 5.34 |
| CHEMBL59592 | — | — | 1 | 5.14 |
| CHEMBL256147 | TILARGININE | 3.0 | 1 | 5.00 |
| CHEMBL61139 | — | — | 1 | 4.90 |
| CHEMBL294044 | — | — | 1 | 4.88 |
| CHEMBL61430 | — | — | 1 | 4.84 |
| CHEMBL59350 | — | — | 1 | 4.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6808 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL294609 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL292507 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL61427 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL61939 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL60372 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL299677 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL59925 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL302657 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL40833 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL62077 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL294084 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL61990 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL293022 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL291544 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL61599 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL7889 | L-NIL | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL61236 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL21619 | 2-AMINOPYRIDINE | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL61591 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL292981 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL58492 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL60528 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL62083 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL59592 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL256147 | TILARGININE | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL61139 | — | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL294044 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL61430 | — | IC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL59350 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL299906 | — | IC50 | = | 34500.0 | nM | 4.46 |
| CHEMBL61743 | ISOQUINOLIN-3-AMINE | IC50 | > | 50000.0 | nM | - |
| CHEMBL225304 | PIMAGEDINE | IC50 | = | 101000.0 | nM | - |
| CHEMBL292690 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL59235 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL293728 | — | IC50 | > | 50000.0 | nM | - |