Assay Detail
Functional
CHEMBL700548
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Compound was tested for inhibition activity of human oral carcinoma cell line (KB ) cells in quadruplicate assay.
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | carcinoma cell line |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis of fluorosugar analogues of 2,5,6-trichloro-1-(beta-D-ribofuranosyl)benzimidazole as antivirals with potentially increased glycosidic bond stability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.19 | 4.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL375530 | DICHLORORIBOBENZIMIDAZOLE | — | 1 | 4.44 |
| CHEMBL2367679 | — | — | 1 | 4.22 |
| CHEMBL2367680 | — | — | 1 | 4.10 |
| CHEMBL2367681 | — | — | 1 | 4.00 |
| CHEMBL2367676 | — | — | 1 | - |
| CHEMBL513232 | — | — | 1 | - |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | - |
| CHEMBL2367678 | — | — | 1 | - |
| CHEMBL311377 | — | — | 1 | - |
| CHEMBL473894 | — | — | 1 | - |
| CHEMBL2367682 | — | — | 1 | - |
| CHEMBL2367677 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL375530 | DICHLORORIBOBENZIMIDAZOLE | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL2367679 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL2367680 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL2367681 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL2367676 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL513232 | — | IC50 | = | 210000.0 | nM | - |
| CHEMBL182 | GANCICLOVIR | IC50 | > | 100000.0 | nM | - |
| CHEMBL2367678 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL311377 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL473894 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2367682 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2367677 | — | IC50 | > | 100000.0 | nM | - |