Assay Detail
Binding
CHEMBL700573
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of the binding of radioligand [3H]AMPA in the presence at low-affinity AMPA receptor sites.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic AMPA (CHEMBL2096670) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Homo sapiens |
Publication
Novel class of amino acid antagonists at non-N-methyl-D-aspartic acid excitatory amino acid receptors. Synthesis, in vitro and in vivo pharmacology, and neuroprotection.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.23 | 6.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13378 | (R,S)-AMPA | — | 1 | 6.44 |
| CHEMBL291274 | — | — | 1 | 4.01 |
| CHEMBL1159826 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13378 | (R,S)-AMPA | IC50 | = | 364.0 | nM | 6.44 |
| CHEMBL291274 | — | IC50 | = | 98000.0 | nM | 4.01 |
| CHEMBL1159826 | — | IC50 | = | 335000.0 | nM | - |