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Assay Detail

CHEMBL700711

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxic activity against human epidermoid carcinoma cells (KB)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

ADMET (CHEMBL612558)
Type ADMET

Publication

Synthesis, spectroscopy, and cytotoxicity of glycosylated acetogenin derivatives as promising molecules for cancer therapy.
Queiroz EF, Roblot F, Duret P, Figadère B, Gouyette A, Laprévote O, Serani L, Hocquemiller R.
J Med Chem (2000) 43 : 1604 -1610
PubMed 10780917 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 9 8.13 10.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL43136 1 10.80
CHEMBL41177 SQUAMOCIN 1 9.62
CHEMBL3085423 1 9.02
CHEMBL159 VINBLASTINE 4.0 1 8.92
CHEMBL3085422 1 8.05
CHEMBL3085428 1 7.96
CHEMBL3085427 1 6.44
CHEMBL3085425 1 6.37
CHEMBL3085424 1 5.98

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL43136 EC50 = 0.016 nM 10.80
CHEMBL41177 SQUAMOCIN EC50 = 0.24 nM 9.62
CHEMBL3085423 EC50 = 0.96 nM 9.02
CHEMBL159 VINBLASTINE EC50 = 1.2 nM 8.92
CHEMBL3085422 EC50 = 9.0 nM 8.05
CHEMBL3085428 EC50 = 11.0 nM 7.96
CHEMBL3085427 EC50 = 360.0 nM 6.44
CHEMBL3085425 EC50 = 430.0 nM 6.37
CHEMBL3085424 EC50 = 1050.0 nM 5.98