Assay Detail
Functional
CHEMBL700784
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HER14 (human EGFR overexpressing) cell proliferation.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.27 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL440298 | — | — | 1 | 5.52 |
| CHEMBL56543 | — | — | 1 | 5.46 |
| CHEMBL296407 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL440298 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL56543 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL296407 | — | IC50 | = | 15000.0 | nM | 4.82 |