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Assay Detail

CHEMBL700868

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro inhibition of LTB4 induced neutrophil aggregation was determined
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 1 — Organism
Curated By Expert

Target

Homo sapiens (CHEMBL372)
Type ORGANISM
Organism Homo sapiens

Publication

N-aryl cinnamides: A novel class of rigid and highly potent leukotriene B4 receptor antagonists
Greenspan PD, Main AJ, Bhagwat SS, Barsky LI, Doti RA, Engle AR, Frey LM, Zhou H, Lipson KE, Chin MH, Jackson RH, Uziel-Fusi S
Bioorg Med Chem Lett (1997) 7 : 949 -954
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 6.34 7.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL424779 1 7.52
CHEMBL175073 1 7.38
CHEMBL367943 1 7.08
CHEMBL172974 1 6.99
CHEMBL174638 1 6.76
CHEMBL426773 1 6.60
CHEMBL176903 1 6.37
CHEMBL175128 1 6.08
CHEMBL367291 1 5.99
CHEMBL172201 1 5.99
CHEMBL176747 1 5.67
CHEMBL172091 1 5.62
CHEMBL176974 1 5.47
CHEMBL176748 1 5.18

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL424779 IC50 = 30.0 nM 7.52
CHEMBL175073 IC50 = 42.0 nM 7.38
CHEMBL367943 IC50 = 83.0 nM 7.08
CHEMBL172974 IC50 = 103.0 nM 6.99
CHEMBL174638 IC50 = 173.0 nM 6.76
CHEMBL426773 IC50 = 249.0 nM 6.60
CHEMBL176903 IC50 = 429.0 nM 6.37
CHEMBL175128 IC50 = 839.0 nM 6.08
CHEMBL367291 IC50 = 1021.0 nM 5.99
CHEMBL172201 IC50 = 1021.0 nM 5.99
CHEMBL176747 IC50 = 2161.0 nM 5.67
CHEMBL172091 IC50 = 2409.0 nM 5.62
CHEMBL176974 IC50 = 3417.0 nM 5.47
CHEMBL176748 IC50 = 6587.0 nM 5.18