Assay Detail
Functional
CHEMBL700959
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro growth inhibition of L5178Y-Parental murine leukemia cells by incorporation of [14C]-Thd.
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L5178Y |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
5-Substituted N(4)-hydroxy-2'-deoxycytidines and their 5'-monophosphates: synthesis, conformation, interaction with tumor thymidylate synthase, and in vitro antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.84 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL917 | FLOXURIDINE | 4.0 | 1 | 8.70 |
| CHEMBL265000 | — | — | 1 | 7.58 |
| CHEMBL343881 | — | — | 1 | 5.91 |
| CHEMBL788 | IDOXURIDINE | 4.0 | 1 | 5.27 |
| CHEMBL358849 | — | — | 1 | 5.16 |
| CHEMBL376876 | — | — | 1 | 5.07 |
| CHEMBL222280 | BROXURIDINE | 2.0 | 1 | 4.58 |
| CHEMBL505732 | CHLORODEOXYURIDINE | — | 1 | 4.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL917 | FLOXURIDINE | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL265000 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL343881 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL788 | IDOXURIDINE | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL358849 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL376876 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL222280 | BROXURIDINE | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL505732 | CHLORODEOXYURIDINE | IC50 | = | 33000.0 | nM | 4.48 |