Assay Detail
Functional
CHEMBL700960
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro growth inhibition of FdUrd resistant L5178Y-Resistant murine leukemia cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L5178Y |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
5-Substituted N(4)-hydroxy-2'-deoxycytidines and their 5'-monophosphates: synthesis, conformation, interaction with tumor thymidylate synthase, and in vitro antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.54 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL265000 | — | — | 1 | 7.28 |
| CHEMBL917 | FLOXURIDINE | 4.0 | 1 | 6.85 |
| CHEMBL343881 | — | — | 1 | 5.78 |
| CHEMBL788 | IDOXURIDINE | 4.0 | 1 | 5.62 |
| CHEMBL142540 | — | — | 1 | 5.60 |
| CHEMBL358849 | — | — | 1 | 5.04 |
| CHEMBL376876 | — | — | 1 | 4.96 |
| CHEMBL222280 | BROXURIDINE | 2.0 | 1 | 4.92 |
| CHEMBL505732 | CHLORODEOXYURIDINE | — | 1 | 4.92 |
| CHEMBL143461 | — | — | 1 | 4.47 |
| CHEMBL142873 | — | — | 1 | - |
| CHEMBL142759 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL265000 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL917 | FLOXURIDINE | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL343881 | — | IC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL788 | IDOXURIDINE | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL142540 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL358849 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL376876 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL222280 | BROXURIDINE | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL505732 | CHLORODEOXYURIDINE | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL143461 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL142873 | — | IC50 | = | 163000.0 | nM | - |
| CHEMBL142759 | — | IC50 | = | 193000.0 | nM | - |