Assay Detail
Functional
CHEMBL701070
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Compound was tested for its ability to penetrate the cell wall and inhibit macrophage ACAT in cell culture using murine IC-21 macrophages (MAI)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Tetrazole-substituted ureas as inhibitors of acyl-CoA:cholesterol O-acyltransferase (ACAT). A novel preparation of ureas from weakly nucleophilic amines
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.15 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL52443 | — | — | 1 | 6.62 |
| CHEMBL22373 | CL-976 | — | 1 | 6.40 |
| CHEMBL49524 | — | — | 1 | 6.05 |
| CHEMBL49639 | — | — | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL52443 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL22373 | CL-976 | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL49524 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL49639 | — | IC50 | = | 3100.0 | nM | 5.51 |