Assay Detail
Binding
CHEMBL701146
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity of compound against human inducible nitric oxide synthase
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
1,2-Dihydro-4-quinazolinamines: potent, highly selective inhibitors of inducible nitric oxide synthase which show antiinflammatory activity in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.38 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL354788 | — | — | 1 | 8.70 |
| CHEMBL352659 | — | — | 1 | 7.70 |
| CHEMBL367556 | — | — | 1 | 7.57 |
| CHEMBL174290 | — | — | 1 | 7.46 |
| CHEMBL447183 | — | — | 1 | 7.43 |
| CHEMBL173505 | — | — | 1 | 7.41 |
| CHEMBL366978 | — | — | 1 | 7.33 |
| CHEMBL174310 | — | — | 1 | 7.32 |
| CHEMBL354516 | — | — | 1 | 7.30 |
| CHEMBL170580 | — | — | 1 | 7.17 |
| CHEMBL7889 | L-NIL | — | 1 | 7.00 |
| CHEMBL368636 | — | — | 1 | 6.70 |
| CHEMBL170176 | — | — | 1 | 6.52 |
| CHEMBL256147 | TILARGININE | 3.0 | 1 | 6.47 |
| CHEMBL170770 | — | — | 1 | 6.40 |
| CHEMBL169840 | — | — | 1 | 6.05 |
| CHEMBL173920 | — | — | 1 | 5.96 |
| CHEMBL173274 | — | — | 1 | 5.96 |
| CHEMBL174481 | — | — | 1 | 5.60 |
| CHEMBL225304 | PIMAGEDINE | 2.0 | 1 | 5.41 |
| CHEMBL173172 | — | — | 1 | 5.35 |
| CHEMBL355856 | — | — | 1 | 5.01 |
| CHEMBL7890 | L-NAME | 2.0 | 1 | 4.85 |
| CHEMBL354899 | — | — | 1 | 4.50 |
| CHEMBL171798 | — | — | 1 | 4.40 |
| CHEMBL173006 | — | — | 1 | 4.28 |
| CHEMBL171556 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL354788 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL352659 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL367556 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL174290 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL447183 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL173505 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL366978 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL174310 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL354516 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL170580 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL7889 | L-NIL | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL368636 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL170176 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL256147 | TILARGININE | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL170770 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL169840 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL173920 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL173274 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL174481 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL225304 | PIMAGEDINE | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL173172 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL355856 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL7890 | L-NAME | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL354899 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL171798 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL173006 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL171556 | — | IC50 | ~ | 50000.0 | nM | - |