Assay Detail
Binding
CHEMBL701150
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In vitro inhibition of human Inducible nitric oxide synthase.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
2-aminopyridines as highly selective inducible nitric oxide synthase inhibitors. Differential binding modes dependent on nitrogen substitution.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.58 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL302657 | — | — | 1 | 8.00 |
| CHEMBL113438 | — | — | 1 | 7.58 |
| CHEMBL447183 | — | — | 1 | 7.43 |
| CHEMBL59925 | — | — | 1 | 7.35 |
| CHEMBL112866 | — | — | 1 | 7.28 |
| CHEMBL114551 | GW-274150 | 2.0 | 1 | 7.16 |
| CHEMBL114500 | — | — | 1 | 7.15 |
| CHEMBL112246 | — | — | 1 | 7.05 |
| CHEMBL40833 | — | — | 1 | 6.92 |
| CHEMBL7889 | L-NIL | — | 1 | 6.89 |
| CHEMBL420671 | — | — | 1 | 6.46 |
| CHEMBL112747 | — | — | 1 | 6.28 |
| CHEMBL113793 | — | — | 1 | 6.00 |
| CHEMBL62077 | — | — | 1 | 5.96 |
| CHEMBL112198 | — | — | 1 | 5.42 |
| CHEMBL112247 | — | — | 1 | 4.89 |
| CHEMBL112139 | — | — | 1 | 4.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL302657 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL113438 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL447183 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL59925 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL112866 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL114551 | GW-274150 | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL114500 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL112246 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL40833 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL7889 | L-NIL | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL420671 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL112747 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL113793 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL62077 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL112198 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL112247 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL112139 | — | IC50 | = | 86000.0 | nM | 4.07 |