Assay Detail
Binding
CHEMBL701152
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The compound was evaluated for the inhibitory potencies using human Inducible nitric oxide synthase (hiNOS)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of two positron-labeled nitric oxide synthase inhibitors, S-[11C]methylisothiourea and S-(2-[18F]fluoroethyl)isothiourea, as potential positron emission tomography tracers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.94 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL148951 | — | — | 1 | 6.85 |
| CHEMBL321691 | ETHYLISOTHIOUREA | — | 1 | 6.80 |
| CHEMBL356703 | — | — | 1 | 5.52 |
| CHEMBL256147 | TILARGININE | 3.0 | 1 | 4.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL148951 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL321691 | ETHYLISOTHIOUREA | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL356703 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL256147 | TILARGININE | IC50 | = | 27000.0 | nM | 4.57 |