Assay Detail
Functional
CHEMBL701221
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for the inhibition of LTB4 production in human whole blood (HWB)
46
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Dioxabicyclooctanyl naphthalenenitriles as nonredox 5-lipoxygenase inhibitors: structure-activity relationship study directed toward the improvement of metabolic stability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 46 | 6.57 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99469 | — | — | 1 | 8.00 |
| CHEMBL129056 | — | — | 1 | 7.30 |
| CHEMBL129292 | — | — | 1 | 7.30 |
| CHEMBL339993 | — | — | 1 | 7.30 |
| CHEMBL128300 | — | — | 1 | 7.12 |
| CHEMBL20403 | ZD-2138 | — | 1 | 7.10 |
| CHEMBL338132 | — | — | 1 | 7.10 |
| CHEMBL128821 | — | — | 1 | 7.05 |
| CHEMBL414244 | — | — | 1 | 7.00 |
| CHEMBL129018 | — | — | 1 | 7.00 |
| CHEMBL129916 | — | — | 1 | 7.00 |
| CHEMBL131135 | — | — | 1 | 6.92 |
| CHEMBL127779 | — | — | 1 | 6.89 |
| CHEMBL129478 | — | — | 1 | 6.85 |
| CHEMBL97380 | — | — | 1 | 6.82 |
| CHEMBL128238 | — | — | 2 | 6.75 |
| CHEMBL436595 | — | — | 1 | 6.70 |
| CHEMBL338461 | — | — | 1 | 6.70 |
| CHEMBL434057 | — | — | 1 | 6.58 |
| CHEMBL129167 | — | — | 1 | 6.51 |
| CHEMBL340737 | — | — | 1 | 6.43 |
| CHEMBL414375 | — | — | 1 | 6.39 |
| CHEMBL340795 | — | — | 1 | 6.35 |
| CHEMBL16596 | QUIFLAPON | 2.0 | 1 | 6.30 |
| CHEMBL129253 | — | — | 1 | 6.27 |
| CHEMBL339970 | — | — | 1 | 6.18 |
| CHEMBL129669 | — | — | 1 | 6.17 |
| CHEMBL128751 | — | — | 1 | 6.05 |
| CHEMBL128143 | — | — | 1 | 6.00 |
| CHEMBL340333 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99469 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL129056 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL339993 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL129292 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL128300 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL20403 | ZD-2138 | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL338132 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL128821 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL129018 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL414244 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL129916 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL131135 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL127779 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL129478 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL97380 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL128238 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL338461 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL436595 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL434057 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL129167 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL340737 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL414375 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL340795 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL16596 | QUIFLAPON | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL129253 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL339970 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL129669 | — | IC50 | = | 675.0 | nM | 6.17 |
| CHEMBL128751 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL128143 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL340333 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL340805 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL420145 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL129517 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL93 | ZILEUTON | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL128238 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL128105 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL130963 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL128716 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL128793 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL129258 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL338867 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL128271 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL128094 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL338549 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL421447 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL129351 | — | IC50 | > | 3000.0 | nM | - |