Assay Detail
Functional
CHEMBL701318
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Inhibition of LPS-induced TNF-alpha formation in human whole blood.
18
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Substituted 4-(2,2-diphenylethyl)pyridine-N-oxides as phosphodiesterase-4 inhibitors: SAR study directed toward the improvement of pharmacokinetic parameters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.57 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL323312 | — | — | 5 | 6.52 |
| CHEMBL105164 | — | — | 1 | 6.52 |
| CHEMBL286224 | — | — | 1 | 6.16 |
| CHEMBL103635 | — | — | 1 | 6.00 |
| CHEMBL408345 | — | — | 1 | 5.54 |
| CHEMBL103859 | — | — | 1 | 5.41 |
| CHEMBL318108 | — | — | 1 | 5.24 |
| CHEMBL102718 | — | — | 1 | 5.11 |
| CHEMBL102784 | — | — | 2 | 5.11 |
| CHEMBL105243 | — | — | 1 | 5.10 |
| CHEMBL319858 | — | — | 1 | 4.89 |
| CHEMBL32442 | CDP840 | — | 1 | 4.82 |
| CHEMBL511115 | CILOMILAST | 3.0 | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL323312 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL105164 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL323312 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL323312 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL286224 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL323312 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL103635 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL408345 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL323312 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL103859 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL318108 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL102718 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL102784 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL105243 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL319858 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL32442 | CDP840 | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL511115 | CILOMILAST | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL102784 | — | IC50 | = | 23000.0 | nM | 4.64 |