Assay Detail
Functional
CHEMBL701319
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Inhibition of leukotriene B4 production in human whole blood
27
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Pyrrolidine and piperidine analogues of SC-57461A as potent, orally active inhibitors of leukotriene A(4) hydrolase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.45 | 7.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL112671 | — | — | 1 | 7.31 |
| CHEMBL116174 | — | — | 2 | 6.96 |
| CHEMBL14608 | — | — | 1 | 6.92 |
| CHEMBL114615 | — | — | 1 | 6.89 |
| CHEMBL112522 | — | — | 1 | 6.77 |
| CHEMBL114563 | — | — | 1 | 6.75 |
| CHEMBL115105 | — | — | 1 | 6.72 |
| CHEMBL114591 | — | — | 1 | 6.70 |
| CHEMBL112323 | — | — | 1 | 6.64 |
| CHEMBL115170 | — | — | 1 | 6.62 |
| CHEMBL325273 | — | — | 1 | 6.54 |
| CHEMBL114654 | — | — | 1 | 6.54 |
| CHEMBL432791 | — | — | 1 | 6.52 |
| CHEMBL114264 | — | — | 1 | 6.46 |
| CHEMBL115445 | — | — | 1 | 6.44 |
| CHEMBL115295 | — | — | 1 | 6.40 |
| CHEMBL115603 | — | — | 1 | 6.39 |
| CHEMBL115188 | — | — | 1 | 6.38 |
| CHEMBL115227 | — | — | 1 | 6.36 |
| CHEMBL114494 | — | — | 1 | 6.24 |
| CHEMBL115074 | — | — | 1 | 6.19 |
| CHEMBL115215 | — | — | 1 | 6.16 |
| CHEMBL325057 | — | — | 1 | 6.09 |
| CHEMBL113813 | — | — | 1 | 5.78 |
| CHEMBL115276 | — | — | 1 | 5.73 |
| CHEMBL114777 | — | — | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL112671 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL116174 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL14608 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL114615 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL112522 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL114563 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL115105 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL114591 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL112323 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL115170 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL325273 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL114654 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL432791 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL114264 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL115445 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL115295 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL115603 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL115188 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL115227 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL114494 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL115074 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL115215 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL116174 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL325057 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL113813 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL115276 | — | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL114777 | — | IC50 | = | 2400.0 | nM | 5.62 |