Assay Detail
Functional
CHEMBL701320
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of LPS-stimulated TNF-alpha production in human whole blood
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
CDP840. A prototype of a novel class of orally active anti-inflammatory phosphodiesterase 4 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 5.41 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL286421 | — | — | 1 | 6.85 |
| CHEMBL286118 | — | — | 1 | 6.52 |
| CHEMBL287026 | — | — | 1 | 6.52 |
| CHEMBL35562 | — | — | 1 | 6.29 |
| CHEMBL35011 | — | — | 1 | 5.75 |
| CHEMBL285766 | — | — | 1 | 5.66 |
| CHEMBL416399 | — | — | 1 | 5.66 |
| CHEMBL416045 | — | — | 1 | 5.64 |
| CHEMBL418416 | — | — | 1 | 5.60 |
| CHEMBL287359 | — | — | 1 | 5.60 |
| CHEMBL33021 | — | — | 1 | 5.57 |
| CHEMBL289453 | — | — | 1 | 5.51 |
| CHEMBL433828 | — | — | 1 | 5.37 |
| CHEMBL36559 | — | — | 1 | 5.33 |
| CHEMBL287377 | — | — | 1 | 5.28 |
| CHEMBL33419 | — | — | 1 | 5.23 |
| CHEMBL287167 | — | — | 1 | 5.19 |
| CHEMBL35703 | — | — | 1 | 5.19 |
| CHEMBL36007 | — | — | 1 | 5.19 |
| CHEMBL286603 | — | — | 1 | 5.18 |
| CHEMBL286294 | — | — | 1 | 5.16 |
| CHEMBL35391 | — | — | 1 | 5.16 |
| CHEMBL286119 | — | — | 1 | 5.14 |
| CHEMBL32427 | — | — | 1 | 5.09 |
| CHEMBL32442 | CDP840 | — | 1 | 5.07 |
| CHEMBL285488 | — | — | 1 | 5.06 |
| CHEMBL289012 | — | — | 1 | 4.98 |
| CHEMBL286998 | — | — | 1 | 4.93 |
| CHEMBL35346 | — | — | 1 | 4.89 |
| CHEMBL286921 | — | — | 1 | 4.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL286421 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL286118 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL287026 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL35562 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL35011 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL285766 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL416399 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL416045 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL418416 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL287359 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL33021 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL289453 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL433828 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL36559 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL287377 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL33419 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL287167 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL35703 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL36007 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL286603 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL286294 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL35391 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL286119 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL32427 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL32442 | CDP840 | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL285488 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL289012 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL286998 | — | IC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL35346 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL286921 | — | IC50 | = | 22900.0 | nM | 4.64 |
| CHEMBL36471 | — | IC50 | = | 27600.0 | nM | 4.56 |