Assay Detail
Binding
CHEMBL701396
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Binding to kappa opioid receptor by using [3H]U-69593 as radioligand in guinea pig cerebellum
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Cerebellum |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Palladium-catalyzed synthesis of C3-substituted 3-deoxymorphines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.13 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL70 | MORPHINE | 4.0 | 1 | 6.89 |
| CHEMBL87247 | — | — | 1 | 6.04 |
| CHEMBL82576 | — | — | 1 | 5.29 |
| CHEMBL84484 | — | — | 1 | 5.02 |
| CHEMBL85457 | — | — | 1 | 4.96 |
| CHEMBL442709 | — | — | 1 | 4.82 |
| CHEMBL312013 | — | — | 1 | 4.60 |
| CHEMBL85089 | — | — | 1 | 4.44 |
| CHEMBL83413 | — | — | 1 | 4.12 |
| CHEMBL314923 | — | — | 1 | - |
| CHEMBL440694 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL70 | MORPHINE | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL87247 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL82576 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL84484 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL85457 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL442709 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL312013 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL85089 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL83413 | — | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL314923 | — | IC50 | = | 126000.0 | nM | - |
| CHEMBL440694 | — | IC50 | = | 111000.0 | nM | - |