Assay Detail
Binding
CHEMBL701397
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested in vitro for binding affinity towards kappa opioid receptor by measuring displacement of [3H]EKC from guinea pig brain membranes
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Octahydro-1,2,3,4,4a,5,11,11a-pyrido[3,4-c][1,5]benzoxazepines: conformationally restricted fentanyl analogs
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.35 | 5.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2079569 | — | — | 1 | 5.67 |
| CHEMBL596 | FENTANYL | 4.0 | 1 | 5.23 |
| CHEMBL2079638 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2079569 | — | IC50 | = | 2164.0 | nM | 5.67 |
| CHEMBL596 | FENTANYL | IC50 | = | 5893.0 | nM | 5.23 |
| CHEMBL2079638 | — | IC50 | = | 6986.0 | nM | 5.16 |