Assay Detail
Binding
CHEMBL701403
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Affinity at K opioid receptor on membranes prepared from guinea pig cerebellum by [3H]- 69593 displacement.
21
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Cerebellum |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
EMD 61 753 as a favourable representative of structurally novel arylacetamido-type K opiate receptor agonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 8.24 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58033 | (-)-U-50488 | — | 1 | 9.00 |
| CHEMBL559010 | — | — | 1 | 9.00 |
| CHEMBL540342 | ASIMADOLINE HYDROCHLORIDE | — | 1 | 8.70 |
| CHEMBL555800 | — | — | 2 | 8.52 |
| CHEMBL543707 | — | — | 1 | 8.40 |
| CHEMBL538802 | — | — | 1 | 8.40 |
| CHEMBL543236 | — | — | 1 | 8.40 |
| CHEMBL543476 | — | — | 1 | 8.30 |
| CHEMBL540345 | — | — | 1 | 8.22 |
| CHEMBL543947 | — | — | 1 | 8.22 |
| CHEMBL538063 | — | — | 1 | 8.22 |
| CHEMBL543948 | — | — | 1 | 8.22 |
| CHEMBL540335 | — | — | 1 | 8.15 |
| CHEMBL542036 | — | — | 1 | 8.15 |
| CHEMBL545346 | — | — | 2 | 8.00 |
| CHEMBL553085 | — | — | 1 | 8.00 |
| CHEMBL539317 | — | — | 1 | 7.70 |
| CHEMBL553084 | — | — | 1 | 7.70 |
| CHEMBL552587 | — | — | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58033 | (-)-U-50488 | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL559010 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL540342 | ASIMADOLINE HYDROCHLORIDE | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL555800 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL543707 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL538802 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL543236 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL543476 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL538063 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL543947 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL540345 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL543948 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL542036 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL540335 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL545346 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL545346 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL555800 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL553085 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL539317 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL552587 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL553084 | — | Ki | = | 20.0 | nM | 7.70 |