Assay Detail
Functional
CHEMBL701414
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Compound was tested for its inhibitory concentration against human leukemic lymphoblasts (CEM Cells) and a resistant subline (CEM / MTX).
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Methotrexate analogues. 28. Synthesis and biological evaluation of new gamma-monoamides of aminopterin and methotrexate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.36 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL376180 | AMINOPTERIN | 2.0 | 1 | 6.50 |
| CHEMBL47316 | — | — | 1 | 6.00 |
| CHEMBL46140 | — | — | 1 | 5.22 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 5.18 |
| CHEMBL45572 | — | — | 1 | 4.80 |
| CHEMBL44697 | — | — | 1 | 4.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL376180 | AMINOPTERIN | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL47316 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL46140 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL45572 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL44697 | — | IC50 | = | 36000.0 | nM | 4.44 |