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Assay Detail

CHEMBL701425

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity towards IL-1 beta converting enzyme (ICE)
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Caspase-1 (CHEMBL4801)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

The synthesis and evaluation of peptidyl aspartyl aldehydes as inhibitors of ice.
Mullican MD, Lauffer DJ, Gillespie RJ, Matharu SS, Kay D, Porritt GM, Evans PL, Golec JM, Murcko MA, Luong Y, Raybuck SA, Livingston DJ
Bioorg Med Chem Lett (1994) 4 : 2359 -2364
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 17 6.64 8.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL37630 1 8.22
CHEMBL76199 1 8.12
CHEMBL76863 1 7.55
CHEMBL311315 1 7.38
CHEMBL80694 1 7.23
CHEMBL77475 1 6.92
CHEMBL80739 1 6.30
CHEMBL75643 1 5.77
CHEMBL78028 1 5.68
CHEMBL77345 1 5.62
CHEMBL77260 1 4.30
CHEMBL306324 1 -
CHEMBL76565 1 -
CHEMBL80695 1 -
CHEMBL76972 1 -
CHEMBL80821 1 -
CHEMBL308500 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL37630 Ki = 6.0 nM 8.22
CHEMBL76199 Ki = 7.5 nM 8.12
CHEMBL76863 Ki = 28.0 nM 7.55
CHEMBL311315 Ki = 42.0 nM 7.38
CHEMBL80694 Ki = 59.0 nM 7.23
CHEMBL77475 Ki = 120.0 nM 6.92
CHEMBL80739 Ki = 500.0 nM 6.30
CHEMBL75643 Ki = 1700.0 nM 5.77
CHEMBL78028 Ki = 2100.0 nM 5.68
CHEMBL77345 Ki = 2400.0 nM 5.62
CHEMBL77260 Ki = 50000.0 nM 4.30
CHEMBL306324 Ki > 20000.0 nM -
CHEMBL76565 Ki > 20000.0 nM -
CHEMBL80695 Ki > 20000.0 nM -
CHEMBL76972 Ki > 20000.0 nM -
CHEMBL80821 Ki > 20000.0 nM -
CHEMBL308500 Ki > 20000.0 nM -