Assay Detail
Functional
CHEMBL701493
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In vitro activity against the amastigote stage of the parasite cultured in mouse fibroblasts (L-6 cells)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L-6 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
The structure-based design and synthesis of selective inhibitors of Trypanosoma cruzi dihydrofolate reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.57 | 5.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 5.04 |
| CHEMBL35427 | — | — | 1 | 4.94 |
| CHEMBL35552 | — | — | 1 | 4.41 |
| CHEMBL265757 | — | — | 1 | 4.27 |
| CHEMBL285474 | — | — | 1 | 4.21 |
| CHEMBL284943 | — | — | 1 | - |
| CHEMBL35364 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL35427 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL35552 | — | IC50 | = | 38800.0 | nM | 4.41 |
| CHEMBL265757 | — | IC50 | = | 53500.0 | nM | 4.27 |
| CHEMBL285474 | — | IC50 | = | 61000.0 | nM | 4.21 |
| CHEMBL284943 | — | IC50 | > | 167000.0 | nM | - |
| CHEMBL35364 | — | IC50 | > | 171000.0 | nM | - |