Assay Detail
Binding
CHEMBL701557
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Ability to bind to Ionotropic glutamate receptor kainate (kainate 2) was evaluated.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, kainate 5 (CHEMBL2675) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
4-Alkyl- and 4-cinnamylglutamic acid analogues are potent GluR5 kainate receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.11 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL275040 | KAINIC ACID | 2.0 | 1 | 8.10 |
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 1 | 6.12 |
| CHEMBL301536 | — | — | 1 | - |
| CHEMBL58590 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL275040 | KAINIC ACID | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL575060 | GLUTAMIC ACID | Ki | = | 750.0 | nM | 6.12 |
| CHEMBL301536 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL58590 | — | Ki | > | 10000.0 | nM | - |