Assay Detail
Binding
CHEMBL701579
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Inhibition of kallikrein with benzoyl-L-arginine ethyl ester as substrate
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Inhibition studies of some serine and thiol proteinases by new leupeptin analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.56 | 4.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2373061 | — | — | 1 | 4.80 |
| CHEMBL2373060 | — | — | 1 | 4.80 |
| CHEMBL2373062 | — | — | 1 | 4.72 |
| CHEMBL2373064 | — | — | 1 | 4.60 |
| CHEMBL2373044 | — | — | 1 | 4.58 |
| CHEMBL2373041 | — | — | 1 | 4.55 |
| CHEMBL2373046 | — | — | 1 | 4.46 |
| CHEMBL191881 | LEUPEPTIN | — | 1 | 4.40 |
| CHEMBL2373053 | — | — | 1 | 4.39 |
| CHEMBL2373047 | — | — | 1 | 4.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2373061 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL2373060 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL2373062 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL2373064 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL2373044 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL2373041 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL2373046 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL191881 | LEUPEPTIN | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL2373053 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL2373047 | — | IC50 | = | 54000.0 | nM | 4.27 |