Assay Detail
Binding
CHEMBL701580
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Inhibitory activity against kallikrein
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and SAR of anthranilamide-based factor Xa inhibitors with improved functional activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.41 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL174499 | — | — | 1 | 6.89 |
| CHEMBL172360 | — | — | 1 | 6.68 |
| CHEMBL175130 | — | — | 1 | 6.52 |
| CHEMBL174558 | — | — | 1 | 6.42 |
| CHEMBL176243 | — | — | 1 | 6.30 |
| CHEMBL369086 | — | — | 1 | 6.30 |
| CHEMBL367953 | — | — | 1 | 6.25 |
| CHEMBL176671 | — | — | 1 | 6.19 |
| CHEMBL369681 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL174499 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL172360 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL175130 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL174558 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL176243 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL369086 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL367953 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL176671 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL369681 | — | IC50 | = | 790.0 | nM | 6.10 |