Assay Detail
Functional
CHEMBL701683
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In vitro inhibition of U 46619 induced aggregation of washed human platelets
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Thromboxane receptor antagonism combined with thromboxane synthase inhibition. 1. (+/-)-(3-pyridinylbicycloheptyl)alkanoic acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.55 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51875 | — | — | 1 | 7.52 |
| CHEMBL280728 | RIDOGREL | 2.0 | 1 | 5.89 |
| CHEMBL301520 | — | — | 1 | 5.82 |
| CHEMBL297712 | — | — | 1 | 5.80 |
| CHEMBL298130 | — | — | 1 | 5.42 |
| CHEMBL430965 | — | — | 1 | 5.37 |
| CHEMBL51158 | — | — | 1 | 5.28 |
| CHEMBL51526 | — | — | 1 | 5.14 |
| CHEMBL299878 | — | — | 1 | 5.01 |
| CHEMBL51949 | — | — | 1 | 4.96 |
| CHEMBL301280 | — | — | 1 | 4.89 |
| CHEMBL51618 | — | — | 1 | - |
| CHEMBL50916 | — | — | 1 | - |
| CHEMBL52344 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51875 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL280728 | RIDOGREL | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL301520 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL297712 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL298130 | — | IC50 | = | 3850.0 | nM | 5.42 |
| CHEMBL430965 | — | IC50 | = | 4290.0 | nM | 5.37 |
| CHEMBL51158 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL51526 | — | IC50 | = | 7250.0 | nM | 5.14 |
| CHEMBL299878 | — | IC50 | = | 9770.0 | nM | 5.01 |
| CHEMBL51949 | — | IC50 | = | 10870.0 | nM | 4.96 |
| CHEMBL301280 | — | IC50 | = | 12980.0 | nM | 4.89 |
| CHEMBL51618 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL50916 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL52344 | — | IC50 | > | 10000.0 | nM | - |