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Assay Detail

CHEMBL701699

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Concentration required for 50% inhibition of K562 human chronic myelogenous leukemia cell growth in MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type K562
Confidence 1 — Organism
Curated By Expert

Target

K562 (CHEMBL385)
Type CELL-LINE
Organism Homo sapiens

Publication

Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers.
Lawrence NJ, Rennison D, Woo M, McGown AT, Hadfield JA.
Bioorg Med Chem Lett (2001) 11 : 51 -54
PubMed 11140732 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.53 7.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL345556 1 7.70
CHEMBL356370 1 7.30
CHEMBL150438 1 6.92
CHEMBL150582 1 6.77
CHEMBL357282 1 6.42
CHEMBL150590 1 5.60
CHEMBL150463 1 5.58
CHEMBL149358 1 5.52
CHEMBL435236 1 4.82
CHEMBL358424 1 4.68
CHEMBL150190 1 4.62
CHEMBL151355 1 4.52
CHEMBL150941 1 4.29
CHEMBL153243 1 4.22
CHEMBL358037 1 4.05

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL345556 IC50 = 20.0 nM 7.70
CHEMBL356370 IC50 = 50.0 nM 7.30
CHEMBL150438 IC50 = 120.0 nM 6.92
CHEMBL150582 IC50 = 170.0 nM 6.77
CHEMBL357282 IC50 = 380.0 nM 6.42
CHEMBL150590 IC50 = 2500.0 nM 5.60
CHEMBL150463 IC50 = 2600.0 nM 5.58
CHEMBL149358 IC50 = 3000.0 nM 5.52
CHEMBL435236 IC50 = 15000.0 nM 4.82
CHEMBL358424 IC50 = 21000.0 nM 4.68
CHEMBL150190 IC50 = 24000.0 nM 4.62
CHEMBL151355 IC50 = 30000.0 nM 4.52
CHEMBL150941 IC50 = 51000.0 nM 4.29
CHEMBL153243 IC50 = 60000.0 nM 4.22
CHEMBL358037 IC50 = 90000.0 nM 4.05