Compound Detail
CHEMBL357282
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Basic Information
| ChEMBL ID | CHEMBL357282 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JZLCFMGTZMFLCI-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
290.3
MW (Da)
3.51
ALogP
5
HBA
0
HBD
46.1
PSA (Ų)
0.81
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.42
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| K562 CHEMBL385 | IC50 | 6.42 | 6.42 | 380.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| K562 | IC50 | = | 380.0 | nM | 6.42 | Concentration required for 50% inhibition of K562 human chronic myelogenous leuk... | 11140732 |
| K562 | IC50 | = | 380.0 | nM | 6.42 | Cytotoxicity against human K562 cells assessed as growth inhibition after 5 days... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11140732 | 10.1016/s0960-894x(00)00596-5 | K562 | 1 |
| - | 10.1039/C2MD20199B | K562 | 1 |
Data from ChEMBL 36 via Core Engine