Assay Detail
Binding
CHEMBL701719
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Inhibition of HIV-1 integrase, under 1 uM for the 3''-preprocessing
26
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Developing a dynamic pharmacophore model for HIV-1 integrase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 5.57 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL63592 | — | — | 1 | 6.82 |
| CHEMBL177126 | — | — | 2 | 6.60 |
| CHEMBL441250 | — | — | 1 | 6.19 |
| CHEMBL431948 | — | — | 1 | 6.17 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.05 |
| CHEMBL292992 | — | — | 1 | 6.05 |
| CHEMBL553067 | — | — | 1 | 5.96 |
| CHEMBL430786 | — | — | 1 | 5.92 |
| CHEMBL413552 | QUERCETAGETIN | — | 1 | 5.89 |
| CHEMBL304722 | — | — | 1 | 5.85 |
| CHEMBL67076 | — | — | 1 | 5.77 |
| CHEMBL164 | MYRICETIN | — | 1 | 5.70 |
| CHEMBL66953 | PURPUROGALLIN | — | 1 | 5.68 |
| CHEMBL541123 | — | — | 1 | 5.64 |
| CHEMBL58 | MITOXANTRONE | 4.0 | 1 | 5.42 |
| CHEMBL29898 | QUINALIZARIN | — | 1 | 5.40 |
| CHEMBL6246 | ELLAGIC ACID | 2.0 | 1 | 5.29 |
| CHEMBL324842 | ROSMARINIC ACID | — | 1 | 5.05 |
| CHEMBL67233 | — | — | 1 | 5.02 |
| CHEMBL67535 | — | — | 1 | 5.00 |
| CHEMBL286494 | HYPERICIN | 3.0 | 1 | 5.00 |
| CHEMBL68073 | — | — | 1 | 4.77 |
| CHEMBL216962 | — | — | 1 | 4.69 |
| CHEMBL66854 | — | — | 1 | 4.62 |
| CHEMBL284616 | CHLOROGENIC ACID | 2.0 | 1 | 4.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL63592 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL177126 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL441250 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL431948 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL177126 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL292992 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL553067 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL430786 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL413552 | QUERCETAGETIN | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL304722 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL67076 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL164 | MYRICETIN | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL66953 | PURPUROGALLIN | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL541123 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL58 | MITOXANTRONE | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL29898 | QUINALIZARIN | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL6246 | ELLAGIC ACID | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL324842 | ROSMARINIC ACID | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL67233 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL286494 | HYPERICIN | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL67535 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL68073 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL216962 | — | IC50 | = | 20600.0 | nM | 4.69 |
| CHEMBL66854 | — | IC50 | = | 23900.0 | nM | 4.62 |
| CHEMBL284616 | CHLOROGENIC ACID | IC50 | = | 87800.0 | nM | 4.06 |