Assay Detail
Binding
CHEMBL701720
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Tested for inhibition of HIV-1 integrase, under 1 uM for the strand transfer
22
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Developing a dynamic pharmacophore model for HIV-1 integrase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.74 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL63592 | — | — | 1 | 6.89 |
| CHEMBL292992 | — | — | 1 | 6.52 |
| CHEMBL177126 | — | — | 2 | 6.34 |
| CHEMBL553067 | — | — | 1 | 6.30 |
| CHEMBL164 | MYRICETIN | — | 1 | 6.22 |
| CHEMBL413552 | QUERCETAGETIN | — | 1 | 6.22 |
| CHEMBL441250 | — | — | 1 | 6.18 |
| CHEMBL67076 | — | — | 1 | 6.00 |
| CHEMBL304722 | — | — | 1 | 6.00 |
| CHEMBL29898 | QUINALIZARIN | — | 1 | 6.00 |
| CHEMBL431948 | — | — | 1 | 5.97 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.62 |
| CHEMBL67535 | — | — | 1 | 5.52 |
| CHEMBL430786 | — | — | 1 | 5.44 |
| CHEMBL541123 | — | — | 1 | 5.39 |
| CHEMBL68073 | — | — | 1 | 5.30 |
| CHEMBL67233 | — | — | 1 | 5.11 |
| CHEMBL58 | MITOXANTRONE | 4.0 | 1 | 5.10 |
| CHEMBL66854 | — | — | 1 | 4.85 |
| CHEMBL216962 | — | — | 1 | 4.71 |
| CHEMBL284616 | CHLOROGENIC ACID | 2.0 | 1 | 4.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL63592 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL292992 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL177126 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL553067 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL177126 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL164 | MYRICETIN | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL413552 | QUERCETAGETIN | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL441250 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL67076 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL304722 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL29898 | QUINALIZARIN | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL431948 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL67535 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL430786 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL541123 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL68073 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL67233 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL58 | MITOXANTRONE | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL66854 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL216962 | — | IC50 | = | 19700.0 | nM | 4.71 |
| CHEMBL284616 | CHLOROGENIC ACID | IC50 | = | 45800.0 | nM | 4.34 |