Assay Detail
Functional
CHEMBL701741
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Compound was tested for cytotoxicity against L1210 cell lines
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biologic activity of 2'-fluoro-2-halo derivatives of 9-beta-D-arabinofuranosyladenine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.24 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1619 | CLADRIBINE | 4.0 | 1 | 7.16 |
| CHEMBL1750 | CLOFARABINE | 4.0 | 1 | 6.64 |
| CHEMBL3143080 | — | — | 1 | 6.58 |
| CHEMBL2092969 | — | — | 1 | 6.42 |
| CHEMBL1229920 | — | — | 1 | 6.05 |
| CHEMBL3143081 | — | — | 1 | 6.05 |
| CHEMBL608646 | — | — | 1 | 5.52 |
| CHEMBL1568 | FLUDARABINE | 3.0 | 1 | 5.52 |
| CHEMBL285819 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1619 | CLADRIBINE | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL1750 | CLOFARABINE | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL3143080 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL2092969 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL1229920 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL3143081 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL608646 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1568 | FLUDARABINE | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL285819 | — | IC50 | < | 3000.0 | nM | - |