Assay Detail
Functional
CHEMBL701752
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Compound was tested for inhibition of rhodamine 123 efflux in mdr 1 transfectant L5178Y VMDRI C.06 mouse lymphoma cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L5178Y |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Substituted 4-acylpyrazoles and 4-acylpyrazolones: synthesis and multidrug resistance-modulating activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 4.84 | 5.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL339825 | — | — | 1 | 5.65 |
| CHEMBL336833 | — | — | 1 | 5.61 |
| CHEMBL128333 | — | — | 1 | 5.40 |
| CHEMBL340648 | — | — | 1 | 4.82 |
| CHEMBL446161 | — | — | 1 | 4.75 |
| CHEMBL130241 | — | — | 1 | 4.66 |
| CHEMBL339154 | — | — | 1 | 4.47 |
| CHEMBL128085 | — | — | 1 | 4.19 |
| CHEMBL338120 | — | — | 1 | 4.02 |
| CHEMBL129228 | — | — | 1 | - |
| CHEMBL338678 | — | — | 1 | - |
| CHEMBL339252 | — | — | 1 | - |
| CHEMBL129427 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL339825 | — | EC50 | = | 2220.0 | nM | 5.65 |
| CHEMBL336833 | — | EC50 | = | 2430.0 | nM | 5.61 |
| CHEMBL128333 | — | EC50 | = | 4020.0 | nM | 5.40 |
| CHEMBL340648 | — | EC50 | = | 15190.0 | nM | 4.82 |
| CHEMBL446161 | — | EC50 | = | 17840.0 | nM | 4.75 |
| CHEMBL130241 | — | EC50 | = | 21910.0 | nM | 4.66 |
| CHEMBL339154 | — | EC50 | = | 34190.0 | nM | 4.47 |
| CHEMBL128085 | — | EC50 | = | 64550.0 | nM | 4.19 |
| CHEMBL338120 | — | EC50 | = | 94740.0 | nM | 4.02 |
| CHEMBL129228 | — | EC50 | = | 225510.0 | nM | - |
| CHEMBL338678 | — | EC50 | = | 173610.0 | nM | - |
| CHEMBL339252 | — | EC50 | = | 167520.0 | nM | - |
| CHEMBL129427 | — | EC50 | = | 648050.0 | nM | - |