Assay Detail
Functional
CHEMBL701761
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Compound was evaluated for its ability to inhibit growth by 50% at 48 hr in L5178Y murine leukemia cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L5178Y |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antiproliferative effects of novel 5'-fluorinated analogues of 5'-deoxy-5'-(methylthio)adenosine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.36 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL606328 | — | — | 1 | 6.16 |
| CHEMBL603180 | — | — | 1 | 5.70 |
| CHEMBL277041 | METHYLTHIOADENOSINE | — | 1 | 4.22 |
| CHEMBL606332 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL606328 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL603180 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL277041 | METHYLTHIOADENOSINE | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL606332 | — | IC50 | = | 200000.0 | nM | - |