Assay Detail
Functional
CHEMBL701785
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Immunosuppressive activity was measured by inhibition of the IL-2 production in Jurkat cells.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | Jurkat |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Peptidyl-prolyl cis-trans isomerase A (CHEMBL1949) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis of non-immunosuppressive cyclophilin-Binding cyclosporin A derivatives as potential anti-HIV-1 drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.81 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 8.70 |
| CHEMBL3038087 | — | — | 1 | 8.52 |
| CHEMBL2407581 | — | — | 1 | 7.82 |
| CHEMBL3038089 | — | — | 1 | 7.72 |
| CHEMBL3038081 | — | — | 1 | 7.33 |
| CHEMBL3038084 | — | — | 1 | 7.21 |
| CHEMBL3038088 | — | — | 1 | 7.01 |
| CHEMBL2407585 | — | — | 1 | 6.96 |
| CHEMBL3038093 | — | — | 1 | 6.89 |
| CHEMBL3038092 | — | — | 1 | 6.78 |
| CHEMBL442519 | — | — | 1 | 6.78 |
| CHEMBL3038085 | — | — | 1 | 6.56 |
| CHEMBL405301 | — | — | 1 | 6.11 |
| CHEMBL3038082 | — | — | 1 | 6.05 |
| CHEMBL3038091 | — | — | 1 | 6.03 |
| CHEMBL3038086 | — | — | 1 | 6.02 |
| CHEMBL1269597 | SCY 635 | 2.0 | 1 | 5.81 |
| CHEMBL3038083 | — | — | 1 | 5.80 |
| CHEMBL3038090 | — | — | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL160 | CYCLOSPORINE | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3038087 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2407581 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3038089 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3038081 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL3038084 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL3038088 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL2407585 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3038093 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL3038092 | — | IC50 | = | 165.0 | nM | 6.78 |
| CHEMBL442519 | — | IC50 | = | 166.0 | nM | 6.78 |
| CHEMBL3038085 | — | IC50 | = | 277.0 | nM | 6.56 |
| CHEMBL405301 | — | IC50 | = | 783.0 | nM | 6.11 |
| CHEMBL3038082 | — | IC50 | = | 882.0 | nM | 6.05 |
| CHEMBL3038091 | — | IC50 | = | 934.0 | nM | 6.03 |
| CHEMBL3038086 | — | IC50 | = | 959.0 | nM | 6.02 |
| CHEMBL1269597 | SCY 635 | IC50 | = | 1549.0 | nM | 5.81 |
| CHEMBL3038083 | — | IC50 | = | 1572.0 | nM | 5.80 |
| CHEMBL3038090 | — | IC50 | = | 6047.0 | nM | 5.22 |