Assay Detail
Functional
CHEMBL701818
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Inhibition of human mixed lymphocyte response (MLR)
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
32-Ascomycinyloxyacetic acid derived immunosuppressants. Independence of immunophilin binding and immunosuppressive potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 9.54 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL295945 | — | — | 1 | 10.70 |
| CHEMBL51334 | — | — | 1 | 10.52 |
| CHEMBL266263 | — | — | 1 | 10.40 |
| CHEMBL263776 | — | — | 1 | 10.30 |
| CHEMBL299549 | — | — | 1 | 10.15 |
| CHEMBL266912 | — | — | 1 | 10.05 |
| CHEMBL432484 | — | — | 1 | 10.00 |
| CHEMBL52035 | — | — | 1 | 9.89 |
| CHEMBL262844 | — | — | 1 | 9.85 |
| CHEMBL52055 | — | — | 1 | 9.85 |
| CHEMBL295372 | — | — | 1 | 9.80 |
| CHEMBL48841 | — | — | 1 | 9.80 |
| CHEMBL274090 | — | — | 1 | 9.64 |
| CHEMBL8597 | ASCOMYCIN | — | 1 | 9.60 |
| CHEMBL299136 | — | — | 1 | 9.59 |
| CHEMBL51424 | — | — | 1 | 9.54 |
| CHEMBL264789 | — | — | 1 | 9.47 |
| CHEMBL48863 | — | — | 1 | 9.33 |
| CHEMBL269732 | TACROLIMUS ANHYDROUS | 4.0 | 1 | 9.32 |
| CHEMBL411841 | — | — | 1 | 9.26 |
| CHEMBL385686 | — | — | 1 | 9.24 |
| CHEMBL262778 | — | — | 1 | 9.19 |
| CHEMBL51523 | — | — | 1 | 9.10 |
| CHEMBL299146 | — | — | 1 | 9.04 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 8.90 |
| CHEMBL296160 | — | — | 1 | 8.12 |
| CHEMBL51516 | — | — | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL295945 | — | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL51334 | — | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL266263 | — | IC50 | = | 0.04 | nM | 10.40 |
| CHEMBL263776 | — | IC50 | = | 0.05 | nM | 10.30 |
| CHEMBL299549 | — | IC50 | = | 0.07 | nM | 10.15 |
| CHEMBL266912 | — | IC50 | = | 0.09 | nM | 10.05 |
| CHEMBL432484 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL52035 | — | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL262844 | — | IC50 | = | 0.14 | nM | 9.85 |
| CHEMBL52055 | — | IC50 | = | 0.14 | nM | 9.85 |
| CHEMBL295372 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL48841 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL274090 | — | IC50 | = | 0.23 | nM | 9.64 |
| CHEMBL8597 | ASCOMYCIN | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL299136 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL51424 | — | IC50 | = | 0.29 | nM | 9.54 |
| CHEMBL264789 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL48863 | — | IC50 | = | 0.47 | nM | 9.33 |
| CHEMBL269732 | TACROLIMUS ANHYDROUS | IC50 | = | 0.48 | nM | 9.32 |
| CHEMBL411841 | — | IC50 | = | 0.55 | nM | 9.26 |
| CHEMBL385686 | — | IC50 | = | 0.58 | nM | 9.24 |
| CHEMBL262778 | — | IC50 | = | 0.64 | nM | 9.19 |
| CHEMBL51523 | — | IC50 | = | 0.79 | nM | 9.10 |
| CHEMBL299146 | — | IC50 | = | 0.91 | nM | 9.04 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 1.27 | nM | 8.90 |
| CHEMBL296160 | — | IC50 | = | 7.62 | nM | 8.12 |
| CHEMBL51516 | — | IC50 | = | 140.0 | nM | 6.85 |