Assay Detail
Binding
CHEMBL701840
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was tested for its ability to inhibit [3H]AMPA binding to Ionotropic glutamate receptor AMPA from rat whole brain
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, AMPA (CHEMBL2093871) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
8-(1H-imidazol-1-yl)-7-nitro-4(5H)-imidazo[1,2-alpha]quinoxalinone and related compounds: synthesis and structure-activity relationships for the AMPA-type non-NMDA receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.13 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222519 | NBQX | — | 1 | 7.22 |
| CHEMBL64058 | — | — | 1 | 7.16 |
| CHEMBL63516 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222519 | NBQX | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL64058 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL63516 | — | Ki | = | 99.0 | nM | 7.00 |